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Books

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Why Diets Fail (2013)


Ten Speed Press 
Pre-Order!


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Animal Models of Eating Disorders (2012)

Springer (Springer/Humana Press). Available now!

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Research Articles

Yarnell S, Oscar-Berman M, Avena NM, Blum K, Gold MS (2013) Pharmacotherapies for Overeating and Obesity. J Genet Syndr Gene Ther 4: 131. PDF

Rada P, Avena NM, Barson JR, Hoebel BG, Leibowitz SF (2012). A high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens. Brain Sci 2(2): 242-53. PDF

Bocarsly ME, Barson JR, Hauca J, Hoebel BG, Leibowitz SF, Avena NM (2012) Effects of perinatal exposure
to palatable diets on body weight and sensitivity to drugs of abuse in rats. Physiol Behav 107(4): 568-75. PDF

Bocarsly M, Berner LA, Hoebel BG, Avena NM. (2011) Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors. Phys Behav 104(5): 865-72. PDF

Bocarsly M, Powell E, Avena NM, Hoebel BG. (2010) High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels. Pharmacol, Biochem and Behav 97(1): 101-6. PDF

Berner LA, Bocarsly ME, Hoebel BG, Avena NM. (2009) Baclofen suppresses binge eating of pure fat but not a sugar-rich or sweet-fat diet. Behav Pharmacol 20(7): 631-4. PDF

Geiger B, Harburcak M, Avena NM, Moyer MC, Hoebel BG, Pothos EN. (2009) Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity. Neurosci 159(4): 1193-9. PDF

Avena NM, Rada P, Hoebel BG. (2008) Underweight rats have enhanced dopamine release and a blunted acetylcholine satiety response in the nucleus accumbens while bingeing on sucrose. Neurosci 156(4): 865-71. PDF

Berner LA, Avena NM, Hoebel BG. (2008) Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity 16(9): 1998-2002. PDF

Avena NM, Bocarsly M, Rada P, Kim A, Hoebel BG. (2008) After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine balance. Phys Behav 94(3): 309-15. PDF

Brown AJ, Avena NM, Hoebel BG. (2008) A high-fat diet prevents and reverses the development of activity-based anorexia in rats. Int J Eating Disorders 41(5): 383-9. PDF

Hoebel BG, Avena NM, Rada P. (2007) Accumbens dopamine-acetylcholine balance in approach and avoidance. Curr Op Pharmacol 7(6): 617-27. PDF

Chang G, Karatayev O, Ahsan R, Avena NM, Lee C, Lewis M, Hoebel BG, Leibowitz SF. (2007) Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: Relationship with circulating triglycerides. Alc Clin and Exp Res 31(2): 249-59. PDF

Avena NM, Rada P, Moise N, Hoebel BG. (2006) Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neurosci 139(3): 813-20. PDF

Rada P, Avena NM, Hoebel BG. (2005) Daily bingeing on sucrose repeatedly releases dopamine in the accumbens shell. Neurosci 134(3): 737-44. PDF

Avena NM, Long K, Hoebel BG. (2005) Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect. Phys Behav 84: 359-62. PDF

Avena NM, Carrillo CA, Needham L, Leibowitz SF, Hoebel BG.  (2004) Sugar-dependent rats show enhanced intake of unsweetened ethanol. Alcohol 34: 203-9. PDF 

Rada P, Avena NM, Leibowitz SF, Hoebel BG. (2004) Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol 33: 91-7. PDF

Spangler R, Wittkowski KM, Goddard NL, Avena NM, Hoebel BG, Leibowitz SF. (2004) Opiate-like effects of sugar on gene expression in reward areas of the rat brain. Mol Brain Res 124:134-42. PDF

Wagner GC, Avena N, Kita T, Nakashima T, Fisher H, Halladay AK. (2004) Risperidone reduction of amphetamine-induced self-injurious behavior in mice. Neuropharmacol 46: 700-8. PDF

Avena NM and Hoebel BG. (2003) A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neurosci122(1): 17-20. PDF

Leibowitz SF, Avena NM,Chang GQ, Karatayev O, Chau D and Hoebel BG. (2003) Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Phys and Behav 79(1): 103-11. PDF

Spangler R, Goddard N, Avena NM, Hoebel B, Leibowitz S. (2003) Elevated D3 dopamine receptor mRNA in dopaminoceptive and dopaminergic regions of the rat brain in response to morphine. Mol Brain Res 111: 74-83. PDF

Avena NM and Hoebel BG. (2003) Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia. Pharmacol Biochem Behav 74(3): 635-9. PDF

Colantuoni C, Rada P, McCarthy J, Patten C, Avena NM, Chadeayne A and Hoebel BG. (2002) Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 10: 478-88. PDF

Review Articles

Avena NM, Murray S, Gold MS (2013). Comparing the effects of food restriction and overeating on brain reward systems. Exp Gerontol Epub ahead of print. PDF

Avena NM, Rada PV. (2012) Cholinergic modulation of food and drug satiety and withdrawal. Phys Behav 106(3): 332-6. PDF

Avena NM, Gold J, Kroll C, Gold MS (2012) Further developments in the neurobiology of food and addiction: Update on the state of the science. Nutrition 28(4): 341-3. PDF

Avena NM, Bocarsly ME (2012) Dysregulation of brain reward systems in eating disorders: Neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa. Neuropharmacol 63: 87-96. PDF

Avena NM, Wang M, Gold MS. (2011) Implications of food addiction and drug use in obesity. Psychiatric Annals 41(10): 478-482. PDF

Avena NM, Bocarsly M, Hoebel BG, Gold MS. (2011) Overlaps in the nosology of substance abuse and overeating: the translational implications of “food addiction.” Curr Drug Abuse Rev. 4(3): 133-9. PDF

Johnson RJ, Gold MS, Johnson DJ, Ishimoto T, Lanaspa MA, Zahniser NR, Avena NM. (2011) Attention-deficit/hyperactivity disorder: Is it time to reappraise the role of sugar consumption? Postgrad Med 123(5): 39-49. PDF

Corwin RL, Avena NM, Boggiano MM. (2011) Feeding and reward: perspectives from three rat models of binge eating. Phys & Behav 104(1): 87-97. PDF

Berner LA, Bocarsly ME, Hoebel BG, Avena NM. (2011) Pharmacological interventions for binge eating: Lessons from animal models, current treatments, and future directions. Curr Pharmaceut Des 17(12): 1180-7. PDF

Avena, NM. (2010) The study of food addiction using animal models of binge eating. Appetite 55(3): 734-7. PDF

Hoebel BG, Avena NM, Rada P. (2009) Natural addiction: A behavioral and neural-circuit model using sugar addiction in rats. J Addict Med 3(1): 33-41. PDF

Avena NM, Rada P, Hoebel BG. (2009) Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutrition 139(3): 623-8. PDF

Avena NM. (2009) Binge eating: Neurochemical insights from animal models. Eating Disorders 17(1): 89-92. PDF

Avena NM, Rada P, Hoebel BG. (2008) Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci & Biobehav Rev 32(1): 20-39. PDF

Avena, NM. (2008) Monoclonal antibodies step up to the oncology challenge. Scrip Drug Market
Dev 19(5): 29-31. PDF

Avena, NM. (2008) Diabetes: The evergreen challenge. Scrip World Pharmaceut News 3352: 27-30. PDF

Avena, NM. (2007) Examining the addictive-like properties of binge eating using an animal model of sugar dependence. Exp Clin Psychopharmacol 15(5):481-91. PDF

Avena, NM. (2007). RNAi: the cure for all that ails us? Drug and Market Dev 18(12): 21-3. PDF

Avena, NM. (2007). Update on pharmacotherapies for diabetes. Drug and Market Dev 18(10): 21-24. PDF

Avena, NM. (2007). Treating obesity: Taking an addiction direction. Drug and Market Dev 18(9): 4-7. PDF

Rada P, Avena NM, Hoebel BG. (2005) “Adicción” al azúcar: ¿Mito ó realidad? Revisión. Rev Venez Endocrino Metab 3(2): 2-12. PDF

Lewis ML, Rada P, Johnson DF, Avena NM, Leibowitz SF, Hoebel BG. (2005) Galanin and alcohol dependence: Neurobehavioral research. Neuropeptides 39: 317-21. PDF

Chapters

Bocarsly ME and Avena NM (2012). Animal Models of Binge Eating Palatable Foods: Emergence of Addiction-Like Behaviors and Brain Changes in the Rat. In: Animal Models of Eating Disorders. Avena NM (Ed.). New York, NY: Humana Press. Chapter 11, p. 179-191. PDF

Ahmed S, Avena NM, Berridge K, Gearhardt A, Guillem K (accepted). Food Addiction. In: Springer Encyclopedia: Neuroscience in the 21st Century. Pfaff, D (Ed.). New York: Springer.

Avena NM and Hoebel BG (2012). Bingeing, Withdrawal and Craving: An Animal Model of Sugar Addiction. In: Food and addiction: A comprehension handbook. Gold, MS, Brownell, K (Eds.). New York, NY: Oxford University Press. PDF

Avena NM, Bocarsly ME, Hoebel BG (2012) Animal models of sugar and fat bingeing: Relationship to food addiction and increased body weight. In: Psychiatric Disorders: Methods in Mol Bio. Kobeissy, F (Ed.). 829: 351-65. PDF

Avena NM, Bocarsly ME, Hoebel BG (2011) Food addiction: Analysis with an animal model of sugar bingeing. In: Handbook of Behavior, Food and Nutrition. Preedy, VR et al. (Eds.). New York: Springer Science and Business Media. p. 1687-1704. PDF

Avena NM, Rada P, Bocarsly M, Hoebel BG. (2009) Binge eating in relation to addiction: Evidence from an animal model of sugar addiction. In: Binge Eating: Psychological Factors, Symptoms and Treatment. Chambers, N (Ed.). Nova Science Publishers, New York. Chapt.3, p. 95-123. PDF

Hoebel BG, Avena NM, Rada P. (2008) An accumbens dopamine-acetylcholine system for approach and avoidance. In: The Handbook of Approach and Avoidance. Elliot, A (Ed.). New York: Psychology Press; Taylor and Francis Group. p.89-108. PDF

Rada P, Paez X, Hernandez L, Avena NM, Hoebel BG. (2007) Microdialysis in the study of behavior reinforcement and inhibition. In: Handbook of Microdialysis: Methods, Application and Perspectives. Westerink, B, Creamers, T (Eds.). New York: Academic Press. p. 351-75. PDF

Avena NM, Rada PV, Hoebel BG. (2006) Sugar bingeing in rats. Unit 9.23C. In: Current Protocols in Neuroscience. Crawley, JN, Gerfen, CR, Rogawski, MA, Sibley DR, Skolnick, P, Wray, S (Eds.). New York: John Wiley and Sons, Inc. p. 9.23C.1-6. PDF


Letters/Commentaries/Editorials

Avena NM, Gearhardt A, Gold MS, Wang GJ, Potenza MN (2012). Tossing the baby out with the bathwater after a brief rinse? The potential downside of dismissing food addiction based on limited data. Nature Reviews Neuroscience 13: 514. PDF

Avena NM (2011) Editorial: Food and Addiction: Implications and relevance to eating disorders and obesity. Curr Drug Abuse Rev 4(3): 131-2. PDF

Avena NM, Gold MS. (2011) Food and addiction: Sugars, fats and hedonic overeating. Invited commentary on: Gearhert et al., Can food be addictive?: Public health and policy implications. Addiction 106(7): 1214-5. PDF

Avena NM, Gold MS. (2011) Variety and hyperpalatability: Are they promoting addictive overeating? AM J Clin Nut 94(2): 367-8. PDF

Avena NM, Gold MS. (2011) Sensitivity to alcohol in obese patients: A possible role for food addiction. J AM Coll of Surg213(3): 451-2. PDF

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